Abstract

Pregnancy can significantly change the pharmacokinetics of drugs, including those renally secreted by organic anion transporters (OATs). Quantifying these changes in pregnant women is logistically and ethically challenging. Hence, predicting the in vivo plasma renal secretory clearance (CL_秒）和肾cl（cl_ren）怀孕的燕麦药物对于设计燕麦药物的正确给药方案非常重要。在这里，首先使用可用的选择性燕麦探针药物CL量化孕妇肾燕麦活性的折叠变化。_rendata (training dataset; OAT1: tenofovir, OAT2: acyclovir, OAT3: oseltamivir carboxylate). The fold-change in OAT1 activity during the 2^ndand 3^RD.与非妊娠个体相比，三孕酮为2.9和1.0。oat2活动在3时增加3.1倍^RD.三个月。oat3活动在1中增加2.2,1.7和1.3倍^英石那2^nd和3.^RD.三个月分别。根据这些数据，我们预测了CL_秒，Cl._renand total clearance ((CL_total) of drugs in pregnancy, which are secreted by multiple OATs (verification dataset; amoxicillin, pravastatin, cefazolin and ketorolac,R.-ketorolac，S.-ketorolac). Then, the predicted clearances (CLs) were compared with the observed values. The predicted/observed CL_秒，Cl._ren和cl._total除CL外，妊娠妊娠的药物在0.80-1.25折之内_秒amoxicillin在3中^RD.2中妊娠早期（0.76倍）和Cefazolin^nd三个月（1.27倍）。总的来说，我们成功预测了CL_秒，Cl._ren和cl._total怀孕中的药物被多个燕麦肾分泌。将来可以使用这种方法来调整给孕妇给予孕妇的肾分泌燕麦药物的剂量方案。