ty -jour t1-大鼠中的脱栓苯基苯基醚:吸收,分布,代谢和排泄JF-药物代谢和处置JO -Drug Metab Disbos SP -900 LP -907 do -10.1124/dmd.31.7.900 亚博体育appvl -31 is-31 is-31 is-31 is-317 Au -Mörck,Anna au -Hakk,Heldur au -Örn,Ulrika au -Wehler,Eva Klasson Y1-2003/07/01 UR -http://http://www.3tejia.com/content.org/content/31/71/700.abstractN2-最常用的多溴二苯基醚在用作火焰的二苯基乙醚(Depabromodiphenyl-醚(脱发)中,是最常用的。尽管使用了大量使用,但尚未解决代谢途径和吸收,并且对其毒理学的研究很少。在这项工作中,表明在对大鼠的单一口服剂量14C标记后,至少有10%的脱蛋白剂量被吸收。常规大鼠中的主要排泄途径是通过含有90%脱发剂量的粪便。胆汁的排泄量接近剂量的10%,主要代表代谢物。不能排除大于10%的口服剂量被吸收,因为在粪便中排泄的65%的放射性是代谢物。在血浆和富含血液的组织中发现了脂质重量的最高浓度,脂肪组织的脱发浓度最低。酚类分数衍生化后,气相色谱质量光谱法(GC/MS)分析表明,具有五到七个溴原子的代谢产物形成,并且它们具有其中一个环中的豚鼠结构(羟基和一个甲氧基)。 In addition, traces of nonabrominated diphenyl ethers and monohydroxylated metabolites were found by GC/MS. Metabolites, characterized by their chemical properties, were interpreted to be covalently bound to macromolecules, either proteins or lipids. In addition, water solubility was suggested. The metabolic pathway was indicated to include a reactive intermediate. The American Society for Pharmacology and Experimental Therapeutics ER -