TY-Jour T1 - 大鼠中的Decabromodhenyl醚:吸收,分布,新陈代谢和排泄JF - 药物代谢和散配Jo - 药物元代谢SP - 900 LP - 907 Do - 10.1124亚博体育app / DMD.31.7.900 VL - 31是 -7 Au - Mörck,Anna Au - Hakk,Holdur Au - Örn,Ulrika Au - Wehler,Eva Klasson Y1 - 2003/07/01 UR - //www.3tejia.com/content/31/7/900.AbstractN 2 - 在用作阻燃剂的多溴苯基醚中,全溴化二苯基醚,Decabromodhenyl醚(DecaBDE)是最常用的。尽管使用了大片的巨大用途,但代谢途径也没有得到解决,并且对其毒理学进行了很少的研究。在这项工作中,显示在单个口服剂量的14℃标记的DECABDE至大鼠之后,至少10%的DECABDE剂量被吸收。常规大鼠的主要排泄途径是通过含有90%的DECABDE剂量的粪便。胆汁的排泄接近剂量的10%,主要代谢物。由于粪便中排出的65%的放射性是代谢物,因此不能排除在粪便中的65%的放射性被吸收。在血浆和血液中的组织中发现了脂质重量的最高浓度,并且脂肪组织具有最低浓度的DECABDE。在衍生化酚类级分的衍生化后,气相色谱 - 质谱(GC / MS)分析表明,具有五到七个溴原子的代谢物形成,并且它们在其中一个环中具有Guaiacol结构(羟基和甲氧基)。 In addition, traces of nonabrominated diphenyl ethers and monohydroxylated metabolites were found by GC/MS. Metabolites, characterized by their chemical properties, were interpreted to be covalently bound to macromolecules, either proteins or lipids. In addition, water solubility was suggested. The metabolic pathway was indicated to include a reactive intermediate. The American Society for Pharmacology and Experimental Therapeutics ER -