Ty - jour t1 -十溴二苯醚在大鼠中的作用:吸收、分布、代谢和排泄JF -药物代谢和性格乔-药物金属底座Dispos SP - 900 LP - 907 - 亚博体育app10.1124 / dmd.31.7.900六世- 31 - 7盟莫克,安娜盟——Hakk Heldur盟中,Ulrika AU -威尔Eva Klasson Y1 - 2003/07/01 UR - //www.3tejia.com/content/31/7/900.abstract N2 -在用作阻燃剂的多溴二苯醚中,全溴二苯醚,十溴二苯醚(decaBDE)是最常用的。尽管十溴二苯醚的大量使用,但其代谢途径和吸收尚未得到解决,其毒理学研究也很少。在这项工作中,我们发现,大鼠口服14c标记的十溴二苯醚单次剂量后,至少10%的十溴二苯醚剂量被吸收。常规大鼠的主要排泄途径是通过含有90%十溴二苯醚剂量的粪便。胆汁排泄量接近10%,主要为代谢物。粪便排出的放射性物质中有65%为代谢物,因此不能排除口服剂量吸收超过10%的情况。以脂质重量为基础的浓度最高的是血浆和血液丰富的组织,而脂肪组织的十溴二苯醚浓度最低。酚组分衍生后,气相色谱-质谱分析(GC/MS)表明,代谢产物中有5 ~ 7个溴原子,并且在一个环上具有愈创木酚结构(一个羟基和一个甲氧基)。 In addition, traces of nonabrominated diphenyl ethers and monohydroxylated metabolites were found by GC/MS. Metabolites, characterized by their chemical properties, were interpreted to be covalently bound to macromolecules, either proteins or lipids. In addition, water solubility was suggested. The metabolic pathway was indicated to include a reactive intermediate. The American Society for Pharmacology and Experimental Therapeutics ER -